Palladium Nanoparticles Supported on Smopex-234® as Valuable Catalysts for the Synthesis of Heterocycles

Supported catalysts are important tools for developing green-economy-based processes. Palladium nanoparticles (NPs) that immobilized on two fibers developed as metal scavengers (i.e., Smopex®-234 and Smopex®-111, 1% w/w) have been prepared tested in copper-free cyclocarbonylative Sonogashira reactions. Their catalytic activity has compared with of a homogeneous catalyst PdCl2(PPh3)2). Pd/Smopex®-234 showed high selectivity the synthesis functionalized heterocycles, such phthalans isochromans, even when working very low amount palladium (0.2–0.5 mol%). The extension promoted reactions to propargyl homopropargyl amides afforded corresponding isoindoline dihydrobenzazepine derivatives. A preliminary test Pd NPs leaching into solution (1.7 × 10?3 mg) seems indicate that, at end reaction, almost all active is present fiber surface.